Formulation and in Vitro & in Vivo Evaluation of Oral Dispersible Films of Lornoxicam

The aim of the present study is to formulate and evaluate the Immediate release oral dispersible film formulation of lornoxicam with different ratios polymeric combinations by the solvent evaporation technique. . Lornoxicam, a potent non-steroidal antiinflammatory drug (NSAID) with shorter half life, makes the development of immediate release dosage forms extremely advantageous. These formulations are named as F1 to F7 and studied for Thickness, mean weight(mg), drug content(mg),% hydration, % moisture loss , surface PH, Tensile strength, % elongation at break, folding endurance, mucoadhesion time, disintegration time. And these are also studied for In vitro dissolution and In vivo dissolution studies. Among all the formulations F4 with combination of polymers (1:1) showed maximum release of 98 % in 15min, with peak plasma concentration 10.54 mcg/ml emerging to be ideal formulations. The developed Oral dispersible films increase the efficacy of Lornoxicam for the therapy of arthritis and other painful muscular conditions.